beta-agonist-induced inhibitory-guanine-nucleotide-binding regulatory protein coupling to adenylate cyclase in mollusc Anodonta cygnea foot muscle sarcolemma
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چکیده
منابع مشابه
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.
Attenuation of GTP-dependent inhibition of adenylate cyclase by islet-activating protein (pertussis toxin) is due to the ability of the toxin to catalyze the ADP-ribosylation of a 41,000/35,000-Da membrane-bound protein, which is thought to be the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase (Gi). We describe and document the purification of this protein from ...
متن کاملProgesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein.
Previous studies have shown that ripe Xenopus 00cytes, 1.4 mm in diameter and suitable for microinjection, undergo meiotic cell division in response to progesterone by a mechanism involving a decrease in the level of CAMP. In order to investigate the mechanism by which the level of CAMP is reduced by progesterone treatment, adenylate cyclase activity was measured in manually dissected plasma me...
متن کاملFluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein.
Adenylate cyclase in turkey erythrocyte membranes is activated only slowly by guanylyl-8,y-imidodiphosphate (GPP(NH)P) in the absence of isoproterenol but is responsive to fluoride. Incubation of membranes with isoproterenol and GMP allows subsequent isoproterenol-independent stimulation by GPP(NH)P and causes a decline in fluoride-stimulated enzyme activity. The decrement in fluoride activatio...
متن کاملDevelopment of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.
Parasympathetic and sympathetic innervation of the embryonic chick heart proceed non-coordinately. beta-Adrenergic agonists mediate an increase in beating rate in embryonic chick heart prior to ingrowth of the vagus nerve (Culver, N. G., and Fishman, D. A. (1977) Am. J. Physiol. 232, R116-R123) while muscarinic agonists exert relatively little effect on beating rate in hearts 2-4 days in ovo (P...
متن کاملAmiloride interacts with guanine nucleotide regulatory proteins and attenuates the hormonal inhibition of adenylate cyclase.
The effect of amiloride on the hormonal regulation of adenylate cyclase was studied in the rat anterior pituitary. The diuretic did not alter basal adenylate cyclase but augmented the enzyme activity in an irreversible manner in the presence of guanosine 5'-O-(thiotriphosphate) (GTP gamma S) stimulated adenylate cyclase at lower concentrations and inhibited at higher concentrations. Amiloride t...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1992
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1992.tb17418.x